Hemolytic disease of the newborn

Hemolytic Disease of the Newborn

Hemolytic disease of the newborn (HDN), with high potential for increased fetal loss is less common now, due to the universal screening for iso-sensitization and also because of appropriate use of antenatal anti-RhD antibody prophylaxis. There are other non-RhD antibodies that can cause HDN. In US, we occasionally encounter a highly sensitized fetus with significant morbidity and mortality. In ...

Immunologic Basis and Immunoprophy-laxis of RhD Induced Hemolytic Disease of the Newborn (HDN)

RhD antigen is the most immunogenic and clinically significant antigen of red blood cells after ABO system. It has historically been associated with hemolytic disease of the newborn (HDN) which is now routinely prevented by the administration of polyclonal anti-D immunoglobulin. This management of HDN has proven to be one of the most successful cases of prophylactic treatment based on antibody ...

[prevention of Hemolytic Disease of the Newborn].

Erythrophagocytosis in hemolytic disease of the newborn.

By MARY B. COOPER, B.A., M.T. (ASCP) I N 1909, Buchan and Comrie” reported the occurrence of erythrophagocytes in the peripheral blood of 2. newborn infants with ‘ ‘congenital anemia and enlargement of the spleen. ‘ ‘ In 193 I , Abt2 described these cells in blood smears of a case of anemia of the newborn. In 1938, Wyatt, Cooper and Groat9 reported 3 cases of the same disease in which the cells...

Hemolytic disease of the fetus and newborn.

KM The primary cause, of course, is maternal antibodies to red blood cells. Their formation usually occurs at delivery, and in the following pregnancy, those antibodies cross through the placenta and can affect the next fetus. When the antibodies attach to the fetal red blood cells, the cells break down and the fetus becomes anemic. In the United States, the 3 antibodies that cause nearly all t...